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In the context of antiretroviral monotherapy, it is of major concern to study the risk of drug resistance emergence. A suboptimal response was defined as i failure to achieve a decline in the viral load of at least 1.
Resistance testing and pharmacological measurements.
Genotypic resistance testing for all participants was centralized at the Necker Virology Laboratory and was performed by population-based sequencing according to the ANRS method 4. Resistance tests were performed at the time of screening and at the time of virological failure, as previously recommended in the protocol. For patients with these episodes of low-level viremia, the samples obtained at the time of failure were analyzed.
If mutations were detected, the results were compared to those for previously tested samples. Phenotypic resistance tests of all available samples from patients in whom at least one major PI resistance mutation was selected were performed at the baseline and at the time of virological failure by using the PhenoSense GT system Monogram Biosciences, San Francisco, CA.
The LPV concentration in plasma before drug intake was measured by a validated high-performance liquid chromatography assay as described previously 3. Viral subtype determination. The HIV-1 subtype was determined by phylogenetic analyses of reverse transcriptase sequences bp.
The sequences were aligned with those from 37 HIV-1 reference strains www. Statistical analyses. Julie Scanlon and Amy Waste. Sheffield: Sheffield Academic Press, Iasi: Universitas XXI, Bucharest: Univers, Johan de Mylius et.
Volume II, Bodies and Representations. Iasi: Polirom, ISBN X. Editia a doua Bucharest: Univers Enciclopedic Publishing House, Bucharest: Univers Publishing House, March VI: The Secret and the Known.
V: Sites of Memory, No. IV: Orientalism and Occidentalism, no. Bucharest: University of Bucharest, Constanta: Ovidius University Press, ISBN: X. I, no.
Timisoara, Romania, Bucharest: Univers Publishing House. Bucharest: Analele Universitatii Bucuresti, Book reviews Review of Postcolonial Europe? Essays on Post-Communist Literatures and Cultures, eds. Journal of Postcolonial Writing , Louise O.
Comparative Literature Studies Observator cultural No. Ildefonso Falcones has 1 past event.
Become a LibraryThing Author. Ildefonso Falcones is currently considered a "single author.
Ildefonso Falcones is composed of 15 names. You can examine and separate out names. Home Groups Talk Zeitgeist.